姓名：牛银杰
职称：助理研究员
学历、学位：研究生、博士
联系电话：17665120530
电子邮件：niuyinjie0530@163.com
个人简介：
女、博士、中国水产科学研究院"水科英才"青年英才培育对象，现为疫苗创制与疫病区域化控制创新团队主要成员。作为疫苗创制与疫病区域化控制创新团队主要成员。围绕鳜、鲈、鳢等名优鱼类主要疾病，长期从事水产病害防治研究。主持省自然科学基金面上项目1项，国家重点研发计划子任务一项，广州市科技特派员项目1项，广州市科技计划项目1项，所自主创新项目2项，参与支撑计划（攻关计划）、公益性农业行业专项等重大项目30余项，发表文章30余篇，其中SCI收录30篇（第一作者12篇）；获国家发明专利3项，并进行转化，参编专著1部。
研究方向：
围绕两苗一区，聚焦：
1.鳜鲈鳢病毒病的致病机制研究
2.鳜鲈鳢病毒弱毒疫苗的研制
3.鳜鲈鳢病毒疫苗的规模化悬浮制备
构建“基础研究-应用研发-产业转化”全链条技术体系
获奖情况：
鳜鲈鳢病毒病全链条精准防控关键技术研究与示范，2024年中国水产科学研究院科技进步一等奖，第5完成人
近几年代表性论文及其他代表性成果：
1.Yinjie Niu, Caimei Ye, Qiang Lin, Hongru Liang, Xia Luo, Baofu Ma, Ningqiu Li, Xiaozhe Fu. Infectious Spleen and Kidney Necrosis Virus ORF093R and ORF102R Regulate Glutamate Metabolic Reprogramming to Support Virus Proliferation by Interacting with c-Myc. Int J Mol Sci. 2025 Jan 16;26(2):718.
2.Yinjie Niu, Xinmei Yang, Hongru Liang, Xia Luo, Baofu Ma , Qiang Lin, Xiaozhe Fu and Ningqiu Li. scTRIM44 Positively Regulated Siniperca Chuatsi Rhabdovirus Through RIG-I- and MDA5-Mediated Interferon Signaling. Viruses 2024, 16,1876.
3.Yinjie Niu, Saiya Ma, Hongru Liang, Xiaozhe Fu, Baofu Ma, Qiang Lin, Xia Luo and Ningqiu Li. The Stability and Efficency of CPB Cells Were Acclimated for Virus Proliferation. Vaccines 2024, 12, 220.
4.Yinjie Niu, Xiaozhe Fu, Qiang Lin, Hongru Liang, Xia Luo, Shaozhi Zuo, Lihui Liu and Ningqiu Li*. Epidermal growth factor receptor promotes infectiousspleen and kidney necrosis virus invasion via PI3K-Akt signaling pathway. Journal of General Virology 2023;104:001882.
5.Yinjie Niu, Xiaozhe Fu, Qiang Lin, Hongru Liang, Xia Luo, Shaozhi Zuo, Lihui Liu, Ningqiu Li*. In vivo and in vitro, antiviral effects of two mixture of Chinese herbal drug active monomers against MSRV and LMBV in largemouth bass (Micropterus salmoides). Aquaculture 577 (2023) 739977.
6.Yinjie Niu , Xiaozhe Fu , Qiang Lin , Hongru Liang , Xia Luo , Shaozhi Zuo , Lihui Liu , Ningqiu Li*. The composition and antiviral activity of scTRIM59 in Mandarin fish. Fish and Shellfish Immunology 130 (2022) 86–92.
7.Yinjie Niu, Xiaozhe Fu, Qiang Lin, Lihui Liu, Xia Luo, Hongru Liang, Ningqiu Li*. Gefitinib inhibits infectious spleen and kidney necrosis virus infection in vivo and vitro by blocking virus endocytosis. Aquaculture 539 (2021) 736614.
8.Yinjie Niu, Xiaozhe Fu, Lihui Liu, Qiang Lin, Hongru Liang, Zhibin Huang, Ningqiu Li*. Molecular characterization and function of EGFR during viral infection process in Mandarin fishSiniperca chuatsi. Fish and Shellfish Immunology 102 (2020) 211–217.
