李宁求，男，博士，研究员，博士生导师，中国水产科学研究院水产疫苗创制与免疫防控创新团队首席，农业农村部渔用药物创制重点实验室副主任。长期从事鳜鲈鳢等特色鱼类疫苗创制与免疫防控、疫病区域化控制、无病毒苗种繁育与抗病毒新品种选育等，先后主持和参与了国家自然科学基金、国家重点研发计划、国家863计划、国家科技支撑计划（攻关计划）、公益性农业行业专项等重大项目20余项。获各类成果奖励6项、共发表学术论文180余篇（第1作者或通讯作者论文80余篇）、获授权国家发明专利26、参编著作5部。入选中国水产科学研究院“领军人才计划”和“中青年科技拔尖人才”等。
联系方式：
（1）电话：13533755943
（2）邮箱：liningq@126.com
研究方向：
1.病原致病与宿主免疫机制
2.渔用疫苗创制与免疫防控
3.疫病区域化控制技术
4.无病毒苗种繁育与抗病毒新品种选育
主持的重点项目（仅限5项）
1.国家自然科学基金面上项目：ISKNV ORF62L调控IDH重构宿主谷氨酰胺还原性代谢机制研究，项目主持，2023-2026。
2.国家自然科学基金面上项目：ISKNV通过PI3K-Akt-mTOR通路调控鳜脑细胞自噬机制研究，项目主持，2019-2022。
3.国家重点研发计划项目：淡水养殖鱼类重大疫病区域化免疫防控技术及示范，子课题主持，2019-2022.
4.国家重点研发计划项目：水产动物重要病原及其生物学特征与毒力基础，子课题主持，2018-2022.
5.广东省级促进经济高质量发展专项资金：海洋源虹彩病毒高效疫苗创制与应用，项目主持，2022-2024.
代表论文与著作（限第1作者及通讯作者）
1.Fangying Li, Xiaozhe Fu, Xia Luo, Qiang Lin, Hongru Liang,Yinjie Niu, Lihui Liu，Ningqiu Li. Role of asparagine biosynthesis pathway in Siniperca chuatsi rhabdovirus proliferation. Frontiers in Microbiology 2023，14:1165491
2.Yinjie Niu, Xiaozhe Fu, Qiang Lin, Hongru Liang, Xia Luo, Shaozhi Zuo, Lihui Liu and Ningqiu Li*. Epidermal growth factor receptor promotes infectiousspleen and kidney necrosis virus invasion via PI3K-Akt signaling pathway. Journal of General Virology 2023;104:001882
3.Yinjie Niu, Xiaozhe Fu, Qiang Lin, Hongru Liang, Xia Luo, Shaozhi Zuo, Lihui Liu, Ningqiu Li*. In vivo and in vitro, antiviral effects of two mixture of Chinese herbal drug active monomers against MSRV and LMBV in largemouth bass (Micropterus salmoides). Aquaculture 577 (2023) 739977
4.Xiaozhe Fu, Mingju Luo, Guo Zheng，Hongru Liang, Lihui Liu, Qiang Lin, Yinjie Niu, Xia Luo, Ningqiu Li*. Determination and Characterization of a Novel Birnavirus Associated with Massive Mortality in Largemouth Bass. Microbiology Spectrum 2022, 10(2): e01716-21
5.Xiaozhe Fu, Kejin Li, Yinjie Niu, Qiang Lin, Hongru Liang, Xia Luo, Lihui Liu, Ningqiu Li*.The mTOR SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells. Microbiology Spectrum 2022, 10(1): e02310-21
6.Hongru Liang, Xiaozhe Fu, Qiang Lin, Lihui Liu, Zhibin Huang, Yinjie Niu, Luo Xia, Ningqiu Li*.Inhibition of grass carp reovirus with PEGylated aptamers. Aquaculture 559 (2022) 738412
7.Xiaoting Zhang , Yue Ming1, Xiaozhe Fu , Yinjie Niu , Qiang Lin , Hongru Liang , Xia Luo , Lihui Liu , Ningqiu Li*. PI3K/AKT/p53 pathway inhibits infectious spleen and kidney necrosis virus infection by regulating autophagy and immune responses. Fish and Shellfish Immunology 120 (2022) 648–657
8.Yinjie Niu , Xiaozhe Fu , Qiang Lin , Hongru Liang , Xia Luo , Shaozhi Zuo , Lihui Liu , Ningqiu Li*. The composition and antiviral activity of scTRIM59 in Mandarin fish. Fish and Shellfish Immunology 130 (2022) 86–92
9.Yinjie Niu, Xiaozhe Fu, Qiang Lin, Lihui Liu, Xia Luo, Hongru Liang, Ningqiu Li*. Gefitinib inhibits infectious spleen and kidney necrosis virus infection in vivo and vitro by blocking virus endocytosis. Aquaculture 539 (2021) 736614
10.Hongru Liang, Lixi Zhang, Xiaozhe Fu, Qiang Lin, Lihui Liu, Yinjie Niu, Xia Luo, Zhibin Huang and Ningqiu Li*. Development of a double-Antibody Sandwich ELISA for Rapid Detection of the MCP Antigen Concentration in Inactivated ISKNV Vaccines. Vaccines 2021, 9, 1264
11.Xia Luo, Yinjie Niu, Xiaozhe Fu, Qiang Lin, Hongru Liang, Lihui Liu and Ningqiu Li*. Large-Scale Microcarrier Culture of Chinese Perch Brain Cell for Viral Vaccine Production in a Stirred Bioreactor. Vaccines 2021, 9, 1003
12.Xiaozhe Fu, Yue Ming, Chen Li, Yinjie Niu, Qiang Lin, Lihui Liu, Hongru Liang, Zhibin Huang, Ningqiu Li*. Siniperca chuatsi rhabdovirus (SCRV) induces autophagy via PI3K/AktmTOR pathway in CPB cells. Fish and Shellfish Immunology 102 (2020) 381–388.
13.Xiaozhe Fu, Lixi Zhang, Lihui Liu, Qiang Lin, Hongru Liang, Yinjie Niu, Zhibin Huang, Ningqiu Li*. Identification of intron in ORF003 gene and its application for inactivation test of ISKNV. Microbial Pathogenesis 138 (2020) 103822
14.Yinjie Niu, Xiaozhe Fu, Lihui Liu, Qiang Lin, Hongru Liang, Zhibin Huang, Ningqiu Li*. Molecular characterization and function of EGFR during viral infection process in Mandarin fishSiniperca chuatsi. Fish and Shellfish Immunology 102 (2020) 211–217
15.Xixi Guo, Yang Zhou, Xiaozhe Fu, Qiang Lin, Lihui Liu, Hongru Liang, Yinjie Niu, Ningqiu Li*. Transcriptomic profiles reveal that inactivated iridovirus and rhabdovirusbivalent vaccine elicits robust adaptive immune responses against lethal challenge in marbled sleepy goby. Fish and Shellfish Immunology 98 (2020) 429–437
16.Qiang Lin, Jie Li, Xiaozhe Fu, Lihui Liu, Hongru Liang, Yinjie Niu, Chuni Huang,Zhibin Huang, Zhaolan Mo, Ningqiu Li*. Hemorrhagic gill disease of Chinese perch caused byAeromonas salmonicida subsp.salmonicidain China. Aquaculture 519 (2020) 734775
17.Qiang Lin, Xiaozhe Fu, Lihui Liu, Hongru Liang, Yinjie Niu, Yuanya Wen,,Zhibin Huang, Ningqiu Li*. Development and application of a sensitive droplet digital PCR (ddPCR) for the detection of infectious spleen and kidney necrosis virus .Aquaculture，2020，529：735697
