付小哲,女,1978年出生,博士,四级研究员,硕士研究生导师。长期从事水产病害防治研究,围绕鳜、鲈、鳢等名优鱼类主要疾病,开展病原分离鉴定、疫苗研制与免疫防控技术研究,取得较好的研究成果。先后主持国家自然科学基金、广东省海洋渔业科技专项等项目6项,参与国家重点研发计划、国家863、支撑计划(攻关计划)、公益性农业行业专项等重大项目10余项;获得广东省农业技术推广二等奖1项(第八完成人)、中国水产科学研究院科技进步一等奖1项(第十三完成人)、中国水产科学研究院科技进步三等奖1项(第六完成人);申请国家发明专利12项,其中获得专利授权9项(第一发明人2项);发表文章105篇,其中SCI 44篇(第1作者11篇,通讯作者5篇),IF>3.0的28篇,JCR Ⅰ区文章23篇;参编专著2部。
联系方式:
(1)电话:18022410260
(2)邮箱:fuxiaozhe-1998@163.com
(3)通讯地址:广州市荔湾区芳村西朗兴渔路1号,邮编:510380
研究方向:病毒致病机制及免疫防控技术研究
主持的重点项目(列举重大项目5项)
1.国家自然科学基金联合基金重点项目:纳米偶联鳜脾肾坏死病毒主衣壳蛋白疫苗的增效机制研究(U1701233,2018.1-2021.12),265万,子课题主持。
2.国家自然科学基金青年基金:P53介导的鳜传染性脾肾坏死病毒免疫逃逸分子机制研究(31502201,2016.01-2018.12),24万,主持。
3.广东省自然资源厅经济发展项目:鱼类弹状病毒弱毒疫苗关键技术研究及其活疫苗创制(GDME-2018C007,2018.05-2020.05),100万,主持。
4.广东省海洋渔业科技与产业发展专项:鳜虹彩病毒病高毒价细胞灭活疫苗快速制备关键技术研究(A201501B12,2015.01-2017.12),40万,主持。
5. 广东省海洋和渔业发展专项资金(鱼病防治)项目:鳢舒伯特气单胞菌病流行病学与防控技术研究,(2017.1-2018.6),30万,主持。
代表论文与著作(限第1作者及通讯作者)
(1) Fu Xiaozhe, Guo Xixi, Wu Shiwei, Lin Qiang , Liu Lihui, Liang Hongru, Niu Yinjie, Li Ningqiu. Non-Targeted UHPLC-Q-TOF/MS-Based Metabolomics Reveals a Metabolic Shift from Glucose to Glutamine in CPB Cells during ISKNV Infection Cycle. Metabolites, 2019, 9, 174
(2) Guo Xixi, Wu Shiwei, Li Ningqiu, Lin Qiang, Liu Lihui, Liang Hongru, Niu Yinjie, Huang Zhibin, Fu Xiaozhe. Accelerated metabolite levels of aerobic glycolysis and the pentose phosphate pathway are required for efficient replication of infectious spleen and kidney necrosis virus in Chinese perch brain cells. Biomolecules, 2019, 9, 440
(3) Zhang Lijuan, Li Ningqiu, Lin Qian, Liu Lihui, Liang Hongru, Huang Zhibin, Fu Xiaozhe. An avirulent Micropterus salmoides rhabdovirus vaccine candidate protects Chinese perch against rhabdovirus infection Fish and Shellfish Immunology, 2018, 77: 474-480
(4) Xiaozhe Fu, Qiang Lin, Lihui Liu, Hongru Liang, Zhibin Huang, Ningqiu Li*. The pathogenicity and biological features of Santee-Cooper Ranaviruses isolated from Chinese perch and snakehead fish. Microbial Pathogenesis, 2017,112:269–273
(5) Xiaozhe Fu, Qiang Lin, Hongru Liang, Lihui Liu, Zhibin Huang, Ningqiu Li *, Jianguo Su *. The biological features and genetic diversity of novel fish rhabdovirus isolates in China. Archives of Virology, 2017,162:2829–2834
(6) Xiaozhe Fu#, Xianqin Hu#, Ningqiu Li*, Feifei Zheng, Xingxing Dong, Jing Duan, Qiang Lin, Jiagang Tu, Lijuan Zhao, Zhibin Huang, Jianguo Su, Li Lin*. Glutamine and glutaminolysis are required for efficient replication of infectious spleen and kidney necrosis virus in Chinese perch brain cells. Oncotarget, 2017,8(2):2400-2412
(7) Xiaozhe Fu, Ningqiu Li*, Qiang Lin, Lihui Liu, Hongru Liang, Zhibin Huang. Display of ISKNV orf086 protein on the Surface of Aeromonas hydrophila and its immunogenicity in Chinese perch (Siniperca chuatsi). Fish & Shellfish Immunology, 2016, 56: 286-293.
(8) Xiaozhe Fu, Ningqiu Li*, Qiang Lin, Huizhi Guo,Lihui Liu, Shuqin Wu. Early protein ORF086 is an effective vaccine candidate for infectious spleen and kidney necrosis virus in mandarin fish Siniperca chuatsi. Fish & Shellfish Immunology, 2015, 46: 200-205.
(9) Xiaozhe Fu, Ningqiu Li, Yingtiao Lai, Xia Luo, Yingying Wang, Cunbin Shi, Zhibin Huang, Shuqin Wu*, Jianguo Su*. A novel fish cell line derived from the brain of Chinese perch Siniperca chuatsi: Development and characterization,Journal of Fish Biology, 2015, 86, 32-45.