
姓名:付小哲
职称:研究员
学历、学位:研究生、博士
联系电话:18022410260
电子邮件:fuxiaozhe-1998@163.com
个人简介:
女,1978年出生,研究员、博士、硕士生导师。围绕严重危害我国鳜鲈鳢等名优鱼类主要病毒病,从细胞库&病原库建立、病毒致病机制、疫苗构建及质量控制技术等方面,开展鱼类病毒病防治关键技术研究。其中研制的鳜传染性脾肾坏死病毒及弹状病毒二联灭活疫苗成功获得成果转让。先后主持、参加国家重点研发计划、国家科技支撑计划、国家自然科学基金、国家863、948项目、省级专项等各类科研项目等各级项目20多项。获省、市级科技奖励4项;授权国家发明专利19项;发表学术论文150余篇(第一作者或通讯作者40余篇),其中SCI论文60余篇(第一作者或通讯作者40余篇,其中IF>9.0有3篇);制定农业行业标准2项、广东省标准1项;先后参编著作《湖北名优鱼健康养殖技术体系研究》、《兽医生物制品学》(第2版)。被聘为安徽省农业农村柔性引进人才。
研究方向:
1.鱼类病毒致病机制
2.鱼类病毒病疫苗研制
3.疫苗免疫机制
社会兼职:
Fish and Shellfish Immunology、Aquaculture、Vaccine等多个刊物审稿人。
高校校外导师兼职情况:
1.上海海洋大学硕士生导师
2.大连海洋大学硕士生导师
3.天津农学院硕士生导师
获奖情况:
1.中国水产科学研究院科学技术一等奖“鳜鲈鳢病毒病全链条精准防控关键技术研究与示范”(第3完成人,2023)
2.广东省农业技术推广奖二等奖“鳜鱼免疫与生态防控技术示范与推广” (第8完成人,2019)
3.中国水产科学研究院科技进步三等奖“广谱、高效海水鱼弧菌病重组OmpK亚单位疫苗创制与转基因生物安全评价”(第6完成人,2015)
4.中国水产科学研究院科技进步一等奖“海水养殖鱼类哈维氏弧菌、溶藻弧菌二联疫苗研究”,第十三完成人(第13完成人,2009)
近几年代表性论文及其他代表性成果:
1. Xiaozhe Fu, Wenxian Li, Cong Liu, Xia Luo, Qiang Lin, Yinjie Niu, Hongru Liang, Baofu Ma, Ningqiu L. A naturaly attenuated largemouth bass ranavirus strain provided protection for Micropterus salmoides by immersion immunization. Fish and Shellfish Immunology, 2024, 153, 109871
2. Xiaozhe Fu, Mingju Luo, Qiang Lin, Hongru Liang, Yinjie Niu, Xia Luo, Baofu Ma and Ningqiu Li. An Avirulent Largemouth Bass Birnavirus Vaccine Candidate
Protects Largemouth Bass against Birnavirus Infection. Vaccines 2023, 11, 1740
3. Xiaozhe Fu, Kejin Li, Yinjie Niu, Qiang Lin, Hongru Liang, Xia Luo, Lihui Liu, Ningqiu Li. The mTOR/PGC-1a/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells. Microbiology spectrum, 2022, 10 (1): e02310-21
4. Caimei Ye, Shangui Liu, Ningqiu Li, Shaozhi Zuo, Yinjie Niu, Qiang Lin, Hongru Liang, Xia Luo, Xiaozhe Fu*. Mandarin Fish (Siniperca chuatsi) p53 Regulates Glutaminolysis Induced by Virus via the p53/miR145-5p/c-Myc Pathway in Chinese Perch Brain Cells. Microbiology spectrum, 2022, 10 (2) : 10.1128/spectrum.02727-21
5. Xiaozhe Fu, Mingju Luo, Guo Zheng, Hongru Liang, Lihui Liu, Qiang Lin, Yinjie Niu, Xia Luo, Ningqiu Li. Determination and Characterization of a Novel Birnavirus Associated with Massive Mortality in Largemouth Bass. Microbiology spectrum, 2022, 10 (2) : 10.1128/spectrum.01716-21
6. Shangui Liu, Ningqiu Li, Qiang Lin, Lihui Liu, Yinjie Niu, Hongru Liang, Zhibin Huang, Xiaozhe Fu*. Glutaminase 1 in mandarin fish Siniperca chuatsi: Molecular characterization, expression pattern and function involving in virus replication. Aquaculture, 2020, 519, 734924
7. Xiaozhe Fu, Lixi Zhang, Lihui Liu, Qiang Lin, Hongru Liang, Yinjie Niu, Zhibin Huang, Ningqiu Li. Identification of intron in ORF003 gene and its application for inactivation test of ISKNV. Microbial Pathogenesis, 2020, 138, 103822
8. Yinjie Niu, Peng Zhang, Luyao Wang, Ningqiu Li, Qiang Lin, Lihui Liu, Hongru Liang, Zhibin Huang, Xiaozhe Fu∗. Development of double-antibody sandwich ELISA for rapidly quantitative detection of antigen concentration in inactivated SCRV vaccine. Aquaculture, 2020, 520: 734671
9. Xiaozhe Fu, Yue Ming, Chen Li, Yinjie Niu, Qiang Lin, Lihui Liu, Hongru Liang, Zhibin Huang, Ningqiu Li. Siniperca chuatsi rhabdovirus (SCRV) induces autophagy via PI3K/Akt-mTOR pathway in CPB cells. Fish shellfish immunology, 2020, 102: 381-388
10. Zhao Zhao, Chen Zhang, Qiang Lin, Ning-qiu Li, Zhi-Bin Huang, Mi Zhao, Xiao-Zhe Fu∗, Gao-Xue Wang, Bin Zhu. Single-walled carbon nanotubes as delivery vehicles enhance the immunoprotective effect of an immersion DNA vaccine against infectious spleen and kidney necrosis virus in mandarin fish. Fish and Shellfish Immunology, 2020, 432–439
11. 鳜传染性脾肾坏死病毒(ISKNV)ORF093蛋白的应用, 国家发明专利, ZL 201110191339.0, 第一发明人.
12. 鳜鱼脑细胞系的构建方法, 国家发明专利, ZL 201310202902.9, 第1发明人.
13. 一株鱼类弹状病毒弱毒疫苗株,国家发明专利,ZL201711325935.5,第1发明人。
14. 用于检测鳜鱼弹状病毒的试剂盒,国家发明专利,ZL 201910139571.6,第1发明人。
15. ISKNV基因内含子及其在区分ISKNV活病毒与灭活病毒中的应用,ZL20161441036973.6, 第1发明人。