欧密,女,1990年生,博士,副研究员,硕士生导师,中国水产科学研究院鳢和草鱼遗传育种创新团队副首席。入选中国水产科学研究院“百名科技英才”和“水科英才”拔尖人才,担任中国水产学会青年工作委员会委员。主要从事特色淡水养殖鱼类遗传育种与生殖发育研究。先后主持国家自然科学基金面上项目、青年项目、广东省自然科学基金青年提升项目、面上项目等各类项目20余项。以第一/通讯作者(含共同)在Gigascience、Aquaculture等发表学术论文24篇(SCI 18篇,中文核心5篇);授权发明专利9件(第一发明人1件,并转化);发布水产行业标准2项(第一完成人1项)、地方标准1项;作为技术骨干参与培育水产新品种—杂交鳢“雄鳢1号”(GS-02-003-2022)(第三完成人);先后获2023中国农业农村重大科技新成果—新产品类等5项科技奖项。
联系方式:
(1)电话:020-81174522;13925738649
(2)邮箱:om1990@prfri.ac.cn
(3)通讯地址:广州市荔湾区芳村西塱兴渔路1号
研究方向:特色淡水养殖鱼类遗传育种与生殖发育
主持的重点项目(仅列重大项目5项):
1. 国家自然科学基金-面上项目:斑鳢性别决定基因定位与功能鉴定及性别决定机制研究(32373127),2024.01-2027.12,50万元。
2. 国家自然科学基金-青年基金项目:Amh基因在斑鳢性别分化和性腺发育的功能研究(31902351),2020.01-2022.12,21万元。
3. 广东省自然科学基金-青年提升项目:基于原始生殖细胞调控的性控技术研发与全雄斑鳢新种质创制2024.01-2026.12,30万元。
4. 广东省自然科学基金-面上项目:斑鳢两种芳香化酶Cyp19a1a和Cyp19a1b的表达和功能研究(2021A1515012075),2021.01-2023.12,10万元。
5. 2023年高水平广东省农业科技示范市建设资金项目:杂交鳢“雄鳢1号”新品种示范推广,2024.01-2024.12,20万元。
代表论文与著作(限第1作者及通讯作者):
1. Zhang XT, Wu YX, Zhang Y, Zhang J, Chu PF, Chen KC, Liu HY, Luo Q, Fei SZ, Zhao J*, Ou M*. Histological observations and transcriptome analyses reveal the dynamic changes in the gonads of the blotched snakehead (Channa maculata) during sex differentiation and gametogenesis. Biology of Sex Differences, 2024, 15: 70.
2. Liu HY, Zhang J, Cui TX, Xia WW, Luo Q, Fei SZ, Zhu XP, Chen KC, Zhao J*, Ou M*. Genome-wide association studies (GWAS) and transcriptome analysis reveal male heterogametic sex-determining regions and candidate genes in northern snakeheads (Channa argus). International Journal of Molecular Sciences, 2024, 25: 10889.
3. Zhang Y, Lu YT, Xu F, Zhang XT, Wu YX, Zhao J, Luo Q, Liu HY, Chen KC, Fei SZ, Cui XJ, Sun YD*, Ou M*. Molecular characterization, expression pattern, DNA methylation and gene disruption of Figla in Blotched snakehead (Channa maculata). Animals, 2024, 14: 491.
4. Liu HY, Cui TX, Liu HJ, Zhang J, Luo Q, Fei SZ, Chen KC, Zhu XP, Zhu CK, Li BJ, Fang LZ, Zhao J*, Ou M*. Chromosome-level genome assembly of the mud carp (Cirrhinus molitorella) using PacBio HiFi and Hi-C sequencing. Scientific Data, 2024, 11: 1249.
5. Zhang XT, Wu YX, Zhang Y, Zhang J, Chen KC, Liu HY, Luo Q, Luo Q, Zhao J*, Ou M*. Molecular characteristics, expression patterns, and response of insulin-like growth factors gene induced by sex steroid hormones in blotched snakehead (Channa maculata). Fishes, 2024, 9: 120.
6. Zhang Y, Shi JY, Lu YT, Luo Q, Chu PF, Huang R, Chen KC, Zhao J, Wang YP*, Ou M*. Molecular cloning and characterization of scavenger receptor class b type 1 in grass carp (Ctenopharyngodon idellus) and its expression profile following grass carp reovirus challenge. Fishes, 2024, 9: 276.
7. Ou M, Wang F, Li KB, Wu YX, Huang SJ, Luo Q, Liu HY, Zhang XC, Fei SZ, Chen KC*, Zhao J*. Generation of myostatin gene-edited blotched snakehead (Channa maculata) using CRISPR/Cas9 system. Aquaculture, 2023, 563(1): 738988.
8. Huang SJ, Wu YX, Chen KC, Zhang XT, Zhao J, Luo Q, Liu HY, Wang F, Li KB, Fei SZ, Zhang XC, Ou M*. Gene expression and epigenetic modification of aromatase during sex reversal and gonadal development in blotched snakehead (Channa maculata). Fishes, 2023, 8(3): 129.
9. Ou M, Chen KC, Gao DD, Wu YD, Luo Q, Liu HY, Zhao J*. Characterization, expression and CpG methylation analysis of Dmrt1 and its response to steroid hormone in blotched snakehead (Channa maculata). Comparative Biochemistry and Physiology - Part B, 2022, 257: 110672.
10. Ou M, Huang R, Yang C, Gui B, Luo Q, Zhao J, Li YM, Liao LJ, Zhu ZY, Wang YP*, Chen KC*. Chromosome-level genome assemblies of Channa argus and Channa maculata and comparative analysis of their temperature adaptability. Gigascience, 2021, 10: 1-11.
11. Ou M, Chen KC, Luo Q, Liu HY, Wang YP, Chen BX, Liang XQ, Zhao J*. Performance evaluation of XY all-male hybrids derived from XX female Channa argus and YY super-males Channa maculata. Aquaculture Reports, 2021, 20: 100768.
12. Ou M, Chen KC, Gao DD, Wu YD, Chen Z, Luo Q, Liu HY, Zhao J*. Comparative transcriptome analysis on four types of gonadal tissues of blotched snakehead (Channa maculata). Comparative Biochemistry and Physiology - Part D, 2020, 35: 100708.
13. Luo Q#, Ou M#, Zhao J, Liu HY, Gao DD, Wu YD, Zhang LL, Chen KC*. Expression profile and estrogenic regulation of Amh during gonadal sex differentiation in northern snakehead (Channa argus). Genes & Genomics, 2020, 42: 827-835.
14. Ou M, Mao HH, Luo Q, Zhao J, Liu HY, Zhu XP, Chen KC*, Xu HY*. The DNA methylation level is associated with the superior growth of the hybrid fry in snakehead fish (Channa argus × Channa maculata). Gene, 2019, 703: 125-133.
15. Ou M, Huang R, Luo Q, Xiong L, Chen KC*, Wang YP*. Characterisation of scavenger receptor class B type 1 in rare minnow (Gobiocypris rarus). Fish and Shellfish Immunology, 2019, 87: 614-622.
16. Ou M, Zhao J, Luo Q, Hong XY, Zhu XP, Liu HY, Chen KC*. Characteristics of hybrids derived from Channa argus ♀ × Channa maculata ♂. Aquaculture, 2018, 492: 349-356.
17. Ou M, Yang C, Luo Q, Huang R, Zhang AD, Liao LJ, Li YM, He LB, Zhu ZY, Wang YP*. An NGS-based approach for the identification of sex-specific markers in snakehead (Channa argus). Oncotarget, 2017, 8(58): 98733-98744.
18. Ou M, Huang R, Xiong L, Luo LF, Chen G, Liao LJ, Li YM, He LB, Zhu ZY, Wang YP*. Molecular cloning of the MARCH family in grass carp (Ctenopharyngodon idella) and their response to grass carp reovirus challenge. Fish and Shellfish Immunology, 2017, 87: 614-622.
19. 吴玉霞, 张啸天, 张扬, 赵建, 罗青, 刘海洋, 费树站, 陈昆慈, 欧密*. 斑鳢ghr基因克隆、表达分析及性类固醇激素诱导的响应. 农业生物技术学报, 2024, 32(6): 1371-1384.
20. 黄苏静, 吴玉霞, 夏威威, 张啸天, 赵建, 李凯彬, 罗青, 刘海洋, 费树站, 陈昆慈, 欧密*. 乌鳢三种性腺组织的转录组比较分析. 农业生物技术学报, 2024, 32(2): 379-395.
21. 欧密, 徐晟云, 陈昆慈, 罗青, 刘海洋, 梁新球, 赵建*. 乳酸菌对杂交鳢肠道菌群和生长的影响. 农业生物技术学报, 2022, 30(1): 138-150.
22. 欧密, 赵建, 罗青, 刘海洋, 黄容, 汪亚平, 陈昆慈*. 鳢性别控制育种及应用研究进展. 中国农业科技导报, 2022, 24(2): 11-25.
23. 田雨苏, 孙远东*, 欧密*, 刘雨芳, 崔小娟, 周定港, 车文安. 初探壬基酚致红鲫发育畸形的机制. 水产学报, 2020, 44(8): 1-18.
24. 欧密, 赵建, 刘海洋, 夏威威, 罗青, 张新铖, 陈昆慈, 费树站. 鉴定鳢的引物组合、微卫星标记组合、多重PCR体系及其方法和应用. 发明专利: ZL202211728879.2. 授权公告日: 2023.09.05.
25. 欧密, 赵建, 王建波, 陈昆慈, 罗青, 刘海洋, 郑光明, 尹怡, 尹建雄, 陈柏湘. 行业标准: SC/T 1174-2023 乌鳢人工繁育技术规范.